Among six nuclear receptors examined, only Nur77 significantly enhanced TGFβ-induced CAGA reporter activity in both HEK293T kidney and HCT116 colon cancer cells (Supplementary Fig. 1a, b), indicating the positive role of Nur77 in TGFβ/Smad3 signaling. Here, NR4A1 is linked to malignant colon neoplasm.