SHC1 and gastric cancer: To screen out if any of the binding proteins are potential HER2 downstream regulators, we carried out a gene expression correlation analysis between the identified Shc1 interactors and HER2 expression in 659 gastric cancer specimens obtained from the Gene Expression Omnibus (GEO) database, and 24 HER2-correlated Shc1-binding proteins with spearman coefficient ≥0.3 were screened out (Fig. 1b).