To gain insight into the subset of Shc1-binding proteins and identify the undiscovered downstream axis of HER2, which is involved in gastric tumorigenesis, we mapped the binding proteins associated with Shc1 and screened for the interactors that were correlated with HER2 overexpression and were potential upregulated oncogenes in gastric cancer. This evidence concerns the gene SHC1 and gastric cancer.