SHCBP1 and gastric cancer: We found that TFBG partly suppressed EGF-induced Shc1 and SHCBP1 dissociation, which suggested that the feedback inhibition on Shc1–SHCBP1 of TFBG is one of the reasons why TFBG sensitize gastric cancer to trastuzumab (Supplementary Fig. 9h).