Genetic associations with BMI were enriched in the networks of pancreas (BF = 2.07 × 1013), bowel (BF = 8.02 × 1012), and adipose (BF = 4.73 × 1012), consistent with the roles of obesity-related genes in insulin biology and energy metabolism. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.