Furthermore, we provided new insights that CXCL10 through TLR4, instead of CXCR3, mobilized monocytic MDSCs, but not granulocytic MDSCs, to the liver for facilitating cancer recurrence using CXCL10−/−, CXCR3−/− and TLR4−/− mice. The gene discussed is TLR4; the disease is cancer.