Simultaneously, the circulatory and hepatic monocytic MDSCs were significantly decreased in CXCL10−/− (circulatory: p = 0.0098; hepatic: p = 0.0213) and TLR4−/− (circulatory: p = 0.0134; hepatic: p = 0.0247) mice of IRH with tumor recurrence model (Fig. 6C). The gene discussed is TLR4; the disease is neoplasm.