As expected, rescuing the expression of CYLD by overexpression CYLD dramatically reversed the activation of NF-κB signaling by miR-135b, as indicated by the decreased NF-κB reporter luciferase activity (Fig. 5E) and reduced phosphorylation of p65 in miR-135b overexpressing NSCLC cells (Fig. 5F). The gene discussed is RELA; the disease is non-small cell lung carcinoma.