Our previous in vitro studies implicated NRP2 in promoting survival of cancer cells under chemotherapeutic stress via autophagy.18,19,22 Since we observed increased expression of NRP2 in PCa metastasized to bone, we hypothesized that targeting the NRP2 axis in PCa bone metastasis will sensitize cancer cells to chemotherapy. The gene discussed is NRP2; the disease is posterior cortical atrophy.