NRP2 and posterior cortical atrophy: PCa cells like LNCaP C4-2B, which predominantly form osteosclerotic lesions, activate NRP2 in osteoclasts to inhibit their function; depletion of NRP2 in LNCaP C4-2B CM-treated osteoclasts led to hyper-osteolytic function, which could prove to be fatal if NRP2 inhibition was applied as a therapy for PCa bone metastasis.