Thrombocytopenia (18.3% vs. 0% vs. 23.9%; p-value = 0.01), elevated B2M (58.6% vs. 24.1% vs. 52.2%.; p-value = 0.00), and serum EBV detection rate (40.5% vs. 31.0% vs. 11.9%; p-value = 0.00) were more common in AITL compared to other TFH lymphomas or PTCL-NOS. This evidence concerns the gene B2M and mature T-cell and NK-cell non-Hodgkin lymphoma.