BAX and neoplasm: Addition of NAC or creatine to hypoxic TNBC cells could markedly decrease the level of proapoptotic proteins, including Bax and cleaved Caspase-3, and increased the level of anti-apoptosis protein Bcl-2 and cell viability associated protein Ki-67 (Fig. 7a), as further proved by correspondingly increased hypoxic tumor cell survival (Figure S6A), suggesting that the cytoprotective effects of creatine was partly due to its antioxidant capabilities.