Breast cancers devoid of expression of estrogen receptor alpha (ERα), progesterone receptor (PR) and amplification of human epidermal growth factor receptor 2 (HER2) are classified as triple-negative breast cancer (TNBC), which constitutes about 15% of all breast cancers and is the most aggressive subtype of breast cancer [2]. Here, ESR1 is linked to triple-negative breast carcinoma.