Addition of NAC or creatine to hypoxic TNBC cells could markedly decrease the level of proapoptotic proteins, including Bax and cleaved Caspase-3, and increased the level of anti-apoptosis protein Bcl-2 and cell viability associated protein Ki-67 (Fig. 7a), as further proved by correspondingly increased hypoxic tumor cell survival (Figure S6A), suggesting that the cytoprotective effects of creatine was partly due to its antioxidant capabilities. Here, CASP3 is linked to neoplasm.