The conditional medium from hepatoma cell line ML-14a elevated M2-like expression pattern in BMDMs by stimulating sequestosome 1 (p62/SQSTM1) depended ubiquitination of NF-κB p65 followed by autophagy-mediated degradation of NF-κB p65 [256]. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.