HSP90AA1 and colorectal carcinoma: To determine whether PUS7 mediated the biological role of HSP90 in CRC cells, we conducted rescue experiments and the results showed that depletion of PUS7 rescued the HSP90 OE-induced increase in LASP1 protein levels (Fig. 8c) and cell metastasis (Fig. 8d, e) in both DLD1 and HCT-8 cells.