KEGG enrichment data illustrated that PUS7 could alter multiple pathways, including the TNF signalling cascade, IL-17 signalling cascade, chemical carcinogenesis, glycolysis/gluconeogenesis, and complement and coagulation cascades, demonstrating the modulatory roles of PUS7 in CRC tumorigenesis (Fig. 3b). Here, PUS7 is linked to colorectal carcinoma.