TLR4 and atherosclerosis: In addition to enhancing the activity of GN1, TRIM7 has E3 ubiquitin ligase activity (14), and through this function, it participates in several processes including glycogen accumulation (20), cancer development (14, 15, 16, 17), regulation of atherosclerosis (18), and of the toll-like receptor 4–mediated innate response (23).