No statistically significant difference in plasma Nrg4 levels between NAFLD patients with fibrosis (F2-3, ≥7.0 kPa) and NAFLD patients without fibrosis (F0-2, <7.0 kPa) was observed (F0-1: 84.5 [63.2; 97.9], F2-3: 95.8 [69.6; 112.9] (median [Q1, Q3]) P = 0.087). Here, NRG4 is linked to metabolic dysfunction-associated steatotic liver disease.