Plasma Nrg4 levels were not significantly different between NAFLD patients and HC (respectively 89.2 [68.6; 102.2] vs. (89.5 [68.2; 112.2]; data expressed as median and [interquartile range (Q1, Q3)] (p = 0.622) (Fig 1A). Here, NRG4 is linked to metabolic dysfunction-associated steatotic liver disease.