In addition to histone methylation, PRMT5 is known to methylate a wide variety of proteins including PIWI, the spliceosome Sm, EGFR, E2F1, p53, the p65 subunit of NF-kB, and RAD9, to impact a broad spectrum of cell signaling pathways relevant to cancer biology [15,23,24]. The gene discussed is PRMT5; the disease is cancer.