We and others have previously shown PRMT5 to be dysregulated and to contribute to lymphomagenesis in different histologic subtypes, using a variety of experimental in vivo model systems of MCL, DLBCL, acute leukemia, and spontaneous models of oncogenic viral-induced lymphoproliferative disease (EBV-LPD) [17,26,27,33,34]. The gene discussed is PRMT5; the disease is mantle cell lymphoma.