This analysis overlapped significantly with gene expression changes after knock down of EED (a component of PRC2), genes up-regulated in cells overexpressing MYC, genes up-regulated after knock down of SNF5 (a core member of the SWI/SNF chromatin remodeling complex), and genes up-regulated after RB1 knock down (a key tumor suppressor). This evidence concerns the gene RB1 and neoplasm.