Ido1 was not significantly increased in the striatum (F(1,20) = 1.36, p = 0.2581) but was increased in the cortex of HD mice (F(1,20) = 5.86, p = 0.0251) relative to WT mice regardless of NIS (Fig 1C and 1D). The gene discussed is IDO1; the disease is Huntington disease.