This dual positive population has been shown to be a stable Treg lineage with a high suppressive capacity, particularly during the inflammation of mucosal sites such as in the T‐cell transfer colitis model where transfer of Foxp3+RORγt+ Tregs show a more potent suppression compared with Foxp3+RORγt‐ Tregs.46 This evidence concerns the gene FOXP3 and colitis.