INS and breast cancer: It appeared that the extents of activation by IGF2 and insulin were different.Expression levels of genes involved in mitochondrial biogenesis like PGC1α, PRC1, PNC1,NRF-2a, NRF1, TFAM, and MFN1 and genes involved in mitochondrial activity like NFE2L2, COX1,and cytoB were higher in breast cancer cells treated by IGF2 than that in cells treated byinsulin.