IGF2 and obesity due to melanocortin 4 receptor deficiency: However, there is growing evidence that IGF2 regulatesfetal growth and development and as well participates in the development of numerousdiseases such as cancer, obesity, diabetes, and liver diseases (Wang et al., 2003; Vellaand Malaguarnera, 2018; Minchenko et al.,2019; Yu et al., 2019).