As CXCR4 signaling is known to promote cell migration and metastasis (Chatterjee et al,2014), we investigated whether CXCR4 inhibition by AMD had an effect on lung metastasis in the spontaneous NeuNT and grafting NT193 models, respectively, as detailed in Fig 6A, D, and H. Here, CXCR4 is linked to age-related macular degeneration.