CXCL12 and neoplasm: To gain insight into the underlying mechanism, we consulted our RNA‐seq results which revealed 1,502 genes to be differently expressed, including Cxcl12. Here, we focused on CXCL12, a known regulator of tumor immunity (Okabe et al,2005; Zhang et al,2019) that was more expressed in TNC‐high in comparison to TNC‐low (WT/shTNC, KO/shTNC) tumors and in cultured tumor cells which we confirmed by qRT–PCR and ELISA (Figs 3A–C and EV3A and B, Appendix Table S2).