To address a potential role of CXCR4 signaling on homing and tumor outgrowth in the NT193 model, we engrafted shC or shTNC cells via tail vein (iv) injection into a WT host followed by a daily AMD treatment for one week as previously described (Yang et al,2019) (5‐week model, Fig 6D). Here, CXCR4 is linked to age-related macular degeneration.