We investigated whether TNC influenced expression of the CXCL12 receptors CXCR4 and/or CXCR7 (Bleul et al,1996; Balabanian et al,2005) and observed that Cxcr4 levels were higher in TNC‐low (WT/shTNC, KO/shTNC) tumors and in cultured tumor cells upon TNC knockdown, revealing an opposite regulation than Cxcl12 by TNC (Appendix Fig S3A). This evidence concerns the gene ACKR3 and neoplasm.