Next, we addressed how TNC induced Cxcl12 by using inhibitors according to established protocols for tyrosine kinase inhibitors (sunitinib), integrin α4β1 and α9β1 (BOP), TGFβ receptor 1 (TGFβRI, GW788388), and Toll‐like receptor 4 (TLR4, Cli95) on tumor cells stimulated with TNC. This evidence concerns the gene TLR4 and neoplasm.