In particular, the so‐called “immunoscore” takes into account the exclusion of CD8 TIL from tumor cell clusters (Galon & Bruni, 2019) which are often organized as nests surrounded by stroma, that is rich in extracellular matrix (ECM) (Pickup et al,2014; Spenlé et al,2015). The gene discussed is CD8A; the disease is neoplasm.