Furthermore, we detected an increase in LEPR expression in orbital tissues from TAO patients, which corresponds to findings from previous studies that showed increased leptin expression in orbital tissues from patients with TAO and that adipocytes derived from orbital preadipocyte fibroblasts stimulated with TSHR can produce 6‐37 times more leptin than those from controls.33, 34. This evidence concerns the gene LEPR and thromboangiitis obliterans.