Moreover, emerging evidence from animal models of diverse brain pathologies (e.g. Alzheimer's disease, epilepsy, stroke, traumatic brain injury) 81, 83, 86 suggests Tau as a converging protein of neuronal damage between different insults and disorders highlighting its broad neuroplastic and neuropathological role.85 The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.