Despite Tau and its malfunction is increasingly related to deficits of adult brain plasticity under pathological conditions [ e.g. Alzheimer's disease (AD)], it remains unknown whether Tau plays a role in neurogenic process of the subventricular zone‐olfactory bulb system under conditions of chronic stress, a well‐known sculptor of brain and a risk factor for AD. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.