Studies have shown that activation of peroxisome proliferator-activated receptor-gamma (PPARGγ) may inhibit the progression of lung squamous cell carcinoma (LSCC) through the regulation of upstream and downstream marker genes of LSCC, and these genes are involved in tumor-cell proliferation and protein polyubiquitination/ubiquitination [15]. The gene discussed is PPARG; the disease is neoplasm.