There is almost no free β‐catenin in the cytoplasm of normal colonic epithelium, β‐catenin accumulates and evades the proteasomal destruction complex, translocates into the nucleus, interacts with lymphoid enhancer factor/T‐cell factor (LEF/TCF) factors, induces the transactivation of target genes involved in cell proliferation, apoptosis, adhesion and angiogenesis, such as c‐myc, CyclinDl, MMP7, survivin as well as CD44, and promotes the occurrence and metastasis of tumor.43, 44, 45. This evidence concerns the gene HNF4A and neoplasm.