KRAS and neoplasm: As suggested by existing studies, some factors exert vital parts in CRC relapse and metastasis, such as tumor location, clinical‐pathologic stratification, K‐ras mutations, microsatellite instability, mismatch repair genes, COX‐2 expression, circulating tumor DNA, gut microbiota, and so on.5, 6, 7, 8, 9, 10