GSEA showed that Fyn might be kinase target of IBSP and our results verified that the β‐catenin and Fyn phosphorylation degrees were, respectively, downregulated and upregulated after transfection with IBSP‐siRNA and IBSP‐overexpressing plasmid, suggesting that IBSP promoted the CRC development via activation of Fyn/β‐catenin signaling pathway. Here, IBSP is linked to colorectal carcinoma.