ANGPT2 and chronic kidney disease: Angpt2 plays an important role in kidney disease, because it was increased in serum of patients with chronic kidney disease, lupus nephritis, thrombotic microangiopathy or anti‐glomerular basement membrane nephropathy,39, 40, 41 and associated with poor prognosis in hypertension and coronary heart disease and also associated with high risk of acute kidney injury in critically ill patients.42