Among them, most studies have shown that Tie2 activation can reduce permeability and inflammation, stabilize blood vessels and maintain the vascular function (such as stabilizing the blood‐brain barrier,49, 50 reducing inflammation and dysregulation of coagulation in sepsis,51 inhibiting the metastasis of tumour regeneration,52 and repairing Schlemm's canal integrity and reducing intraocular pressure53, 54). This evidence concerns the gene TEK and Sepsis.