Guarneri et al have reported that the prevalence of ONJ in advanced breast cancer patients receiving an angiogenic inhibitor, monoclonal antibody to VEGF (bevacizumab), ranged from 0.3 to 0.4%, whereas the prevalence with bevacizumab and bisphosphonate combination therapy ranged from 0.9 to 2.4% [16]. The gene discussed is VEGFA; the disease is breast cancer.