Osteoporosis, rheumatoid arthritis, Sjögren’s syndrome, sarcoidosis, hypocalcemia, hypoparathyroidism, osteomalacia, vitamin D deficiency, renal dialysis, anemia, Paget’s disease of bone, erythropoietin therapy, cyclophosphamide therapy, alcohol intake, and obesity have also been reported to be systemic risk factors for developing MRONJ [1, 2, 9, 29, 30]. This evidence concerns the gene EPO and obesity due to melanocortin 4 receptor deficiency.