Moreover, while the biologic origin of TMAP has not yet been identified, it is suggested that myosin light-chain (MLC) protein degradation results in the release of TMAP.68 Disruption in MLC isoforms has been observed in COPD subjects with reduced activity and low oxygen supply, yet further work is needed to understand the pathophysiology of TMAP in exacerbations. Here, MLC1 is linked to chronic obstructive pulmonary disease.