ACOT2 and chronic obstructive pulmonary disease: The protein that ACOT2 codes for, Acyl-CoA thioesterase-2, has been shown to facilitate mitochondrial fatty acid oxidation in mouse models and may warrant further study.85 The lack of evidence for genetic regulation in the COPD metabolome may implicate other downstream regulation (e.g., methylation, post-translational modification, and metabolism of exogenous metabolites) having a greater effect.