Prior work in high-risk Alzheimer’s disease individuals (familial, ε3ε4/ε4ε4, tau and amyloid positive cases) has suggested that object-location memory fidelity may be a sensitive marker for preclinical Alzheimer’s disease cases and that this effect can be detected in samples aged 70 and older.18 Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.