Previously, we had observed that cells from Limb Girdle Muscular Dystrophy 2L (LGMD2L) patients, repair poorly due to lack of an ER-localized putative Ca2+ activated chloride channel (CaCC) protein - Anoctamin 5 (ANO5) also called Transmembrane 16E (TMEM16E). The gene discussed is ANO5; the disease is autosomal recessive limb-girdle muscular dystrophy type 2L.