It can regulate host dependency factors involved in the trafficking and nuclear importation of pre-integration complexes such as A Disintegrin And Metalloproteinase 10 (ADAM10), Transportin-3 (TNPO3), Nucleoporin Protein 153 (Nup153), and Lens Epithelium-Derived Growth Factor/protein75 (LEDGF/p75) during HIV-1 infection [47, 48]. Here, PSIP1 is linked to HIV-1 infection.