SP1 and lung cancer: Another study investigated by Wang et al., discovered downregulation of miR-326 in lung cancer cells, further research indicated that upregulation of miR-326 suppressed proliferation, invasion, migration and induced cell apoptosis, cycle arrest of lung cancer in vitro by downregulating Specificity protein 1 transcription factors and inactivation of JAK2/STAT3 and PI3K/AKT signaling pathways [21].