SIM2 and Dravet syndrome: Among these genes, some proposed contributors to DS-associated brain phenotypes were KCNJ6 (potassium inwardly rectifying channel subfamily J member 6), RCAN1 (regulator of calcineurin 1), DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A), SIM2 (SIM bHLH transcription factor 2), DSCAM (DS cell adhesion molecule), GRIK1 (glutamate ionotropic receptor kainate type subunit 1), APP (amyloid beta precursor protein), S100B (S100 calcium binding protein B), SOD1 (superoxide dismutase 1) [4, 5, 6, 7, 8, 9, 10].