Our study is aimed at detecting the expression of SLAM and SAP in patients with Graves' disease (GD) and analyzing the effect of SLAM/SAP on circulating blood CD4<sup>+</sup>CXCR5<sup>+</sup>Foxp3<sup>+</sup> follicular regulatory T (Tfr) cells. The gene discussed is CXCR5; the disease is Graves disease.