Therefore, the changes in serum sPD-L1 levels before and after radiotherapy for nonsmall cell lung cancer were analyzed, so did the correlation of PD-L1 and PD-1 with Akt, mTOR, and HIF-1ɑ proteins, to explore the relevant mechanism of the PD-1/PD-L1 pathway in the occurrence and progression of NSCLS. Here, HIF1A is linked to lung cancer.