The expression of PD-L1 and PD1 was both significantly correlated with the expression of Akt, mTOR, and HIF-1α, indicating that PD-1/PD-L1 may play an important role in the pathogenesis of NSCLC through Akt/mTOR and HIF-1α pathways, but the related mechanisms still needed to be further studied. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.