The overexpression of PARP1 observed in several cancers (Sun et al., 2014; Mazzotta et al., 2016; Wang et al., 2017) can produce an uncontrolled PARylation of HuR that may preclude its caspase processing and thus contribute to tumor development (Ke et al., 2021). This evidence concerns the gene ELAVL1 and neoplasm.