TARDBP and amyotrophic lateral sclerosis: For example, aberrant hyper-phosphorylation, ubiquitylation, acetylation, cysteine oxidation and caspase cleavage of TDP-43 have been related to a pathogenic behavior of this RBP in FTLD and/or ALS, including loss of physiological function, mislocalization and higher aggregation (Buratti, 2018; François-Moutal et al., 2019; Prasad et al., 2019).