Since elevated levels of both COX-2 and cyclin-A proteins are associated to abnormal cellular proliferation, Ser318-phosphorylated HuR has been proposed as a tumor marker for colon carcinoma, where cellular concentrations of this phospho-isoform have also been found increased (Figure 2B) (Doller et al., 2011). This evidence concerns the gene ELAVL1 and neoplasm.