At present, the beneficial impact of a transformation-associated isoform of A2M on tumors and other diseases has been mainly discussed in terms of clearing growth factors, especially TGF-β1, which strongly promotes the malignancy of glioma (Lauer et al., 2001; Wick et al., 2001; Sinnreich et al., 2004). This evidence concerns the gene TGFB1 and central nervous system cancer.