The expression of A2M was shown to be correlated with TMB in BRCA, BLCA, COAD, CESC, HNSC, UCEC, UVM, THCA, thymoma (THYM), TGCT, STAD, pheochromocytoma, and paraganglioma, PAAD, LUSC, LUAD, LIHC, LGG, and LAML (Figure 10B). This evidence concerns the gene A2M and hereditary pheochromocytoma-paraganglioma.