In gastric cancer cells, the level expression of FOXC1 is associated with aberrant activation of Wnt pathway due to FOXC1 binding to DKK1 promoter to negatively regulated its transcription, which could affect the level of phosphate-β-Catenin at Ser33/37/Thr41 in the cytoplasm and contributed β-catenin aberrant cumulation in the cytoplasm. The gene discussed is FOXC1; the disease is gastric cancer.