Considering the role of DKK1 in classic Wnt signaling, We next examined the level of DKK1 expression, which is the antagonist of Wnt signaling, and found that the DKK1 mRNA level increased in FOXC1 KO GC cells and decreased in FOXC1-overexpressing GC cells (Figure 6B; Zhu et al., 2021). This evidence concerns the gene FOXC1 and gastric cancer.