CBL and juvenile myelomonocytic leukemia: Clinical features of patients with germline c-CBL (Casitas B-lineage Lymphoma) mutations partially overlap those of NS, including developmental delays, growth defects, facial dysmorphia, and a predisposition to hematological malignancies, specifically juvenile myelomonocytic leukemia (JMML) (Niemeyer et al., 2010; Perez et al., 2010).