TP53 and cancer: These brca2 mutant studies represent the first FA zebrafish cancer susceptibility models as both the infertile brca2–/– males developed testicular cancer, and tp53 and brca2 double heterozygotes (tp53+/M214K; brca2+/–) or homozygotes (tp53M214K/M214K; brca2–/–) had accelerated cancer development by about 5 months (Rodríguez-Marí et al., 2011).