Monoallelic RUNX1 mutations alone are insufficient to initiation leukemogenesis, rather secondary somatic mutations are required within RUNX1 or other AML-associated genes (Song et al., 1999; Preudhomme et al., 2009; Ripperger et al., 2009; Schmit et al., 2015; Antony-Debré et al., 2016). Here, RUNX1 is linked to acute myeloid leukemia.