TP53 and cancer: Unsurprisingly, many frequently mutated cancer driver genes in sporadic cancers have also been classified as CPGs, such as TP53, APC, BRCA1/2, ATM, and NF1, and as such, the knowledge gained by examining the role of germline CPG mutations will help shed light on the mechanisms of tumor formation for both sporadic and inherited cancers (Lu et al., 2015; Zhang et al., 2015).