TP53 and neoplasm: Neurofibromatosis type 1 modulates neuronal differentiation (Hegedus et al., 2007), and NF1 patients frequently develop benign neurofibromas that can undergo malignant transformation to MPNSTs, commonly through the loss of CDKN2A and p53 as well as amplification of PDGFRA (platelet-derived growth factor receptor A) (Mantripragada et al., 2008; Zietsch et al., 2010; Lee et al., 2014).