BRCA2 and ovarian neoplasm: Female-to-male reversal and male infertility is observed in homozygous brca2 zebrafish mutants (Q658X and ZM_00057434 referred to as brca2–/– and both have a disruption in exon 11 of brca2 which is commonly observed in hereditary breast and ovarian tumors) due to the disruptions in germ cell meiosis after being correctly specified in development (Shive et al., 2010; Rodríguez-Marí et al., 2011).