CCR4-NOT Transcription Complex Subunit 3 (CNOT3), a gene important for regulating mRNA transcription, was identified as the most commonly mutated gene (excluding APC) in 20% of 37 FAP adenomas compared to only 1% in the sporadic/inherited colon cancer subset from the TGCA dataset (Gao J. et al., 2013; Delacruz et al., 2019). This evidence concerns the gene APC and Familial adenomatous polyposis.