TNFSF10 and colorectal cancer: Liu et al. developed a facile synergistic nanoplatform (NanoTRAIL) using iron oxide cluster and tumor necrosis factor-related apoptosis-inducing ligand (TRAI/Apo2L), which could release iron oxide NPs to generate ROS to provoke JNK-autophagy-dependent DR5 upregulation, leading to enhancing TRAIL/Apo2L-induced apoptosis in colorectal cancer (Shi et al., 2020).