KLHDC7B, CASP14, and PRSS1 are putatively oncogenic gene that has been demonstrated in breast cancer (26, 27) and pancreatic cancer (28), and the role of KLHDC7B was correlated with extracellular communication, cell morphology, gene expression, and actin binding (29). This evidence concerns the gene PRSS1 and familial pancreatic carcinoma.