Remarkably, we also found the expression of exosomal GAS5 was significantly negatively associated with the tumor grade and degrees of hematuria (all P < 0.05), whereas, the exosomal KLHDC7B, CASP14, PRSS1, and MIR205HG showed positive correlation with tumor grade and hematuria degrees. This evidence concerns the gene CASP14 and Hematuria.