KLHDC7B, CASP14, and PRSS1 are putatively oncogenic gene that has been demonstrated in breast cancer (26, 27) and pancreatic cancer (28), and the role of KLHDC7B was correlated with extracellular communication, cell morphology, gene expression, and actin binding (29). The gene discussed is CASP14; the disease is familial pancreatic carcinoma.