found that in an ischemic stroke model, the engineered extracellular vesicular rabies virus glycoprotein-circSCMH1 selectively transmits circSCMH1 to the brain and mechanically binds to the transcription factor MeCP2, thus resulting in the inhibition of MeCP2 target gene transcription and promoting the functional recovery of stroke in animals (138). Here, MECP2 is linked to stroke disorder.