Reinstating NR2F1 expression in the BM may prevent dormant DTCs from awakening by promoting cell-intrinsic dormancy programs in prostate and/or HNSCC cells while also reinstating the dormancy niche in the BM by secretion of BMP7 and TGFβ2 (69, 70). Here, TGFB2 is linked to head and neck squamous cell carcinoma.