CD8A and neoplasm: Higher densities of tumor-infiltrating lymphocytes (TILs) with cytotoxic or effector properties (such as Th1, CD8+Tcells, NK cells) are associated with lower recurrence, and better prognosis (10, 12, 13), whereas a greater infiltration with inflammatory Th17 or IL17a cytokines are associated with poorer outcomes (7, 14, 15).