CASP3 and hepatocellular carcinoma: Furthermore, allicin and 5-FU combination therapy enhanced the ROS level in the cell, activated caspase-3 and poly(ADP-ribose) polymerase (PARP), lessened the mitochondrial membrane potential (ΔΨm), and decreased Bcl-2 expression in HCC cells in comparison to treated cells with DMSO, allicin, and 5-FU alone.