In light of awareness that different types of antipsychotics have different effects on PRL, a recent meta-analysis and systematic review demonstrated that patients treated with PRL-raising antipsychotics (typical antipsychotics, risperidone, paliperidone, amisulpride) have a higher risk of BMD loss and osteoporosis than patients receiving PRL-decreasing antipsychotics (Tseng et al., 2015; Lally et al., 2019). The gene discussed is PRL; the disease is osteoporosis.