Among the proteins encoded by the hub genes, TFE3, a transcription factor, has been known to be involved in the onset and progress of cancers by regulating many biological processes, such as energy metabolism, lysosomal biogenesis, and immune response (Beckmann, Su & Kadesch, 1990; Perera et al., 2015; Willett et al., 2017). The gene discussed is TFE3; the disease is cancer.