Mutations in VHL were found to be associated with well-defined tumor borders, nodular tumor enhancement, and the presence of intratumor vasculature, while mutations in BAP1 and KDM5C were highly associated with infiltration of renal veins, with significant differences between solid cc RCC genotypes and cystic cc RCC genotypes and with no mutations in SETD2, KDM5C, and KDM5C in cc RCC genotypes. The gene discussed is SETD2; the disease is renal cell carcinoma.