Overexpression of CSE led to spontaneous apoptosis in human melanoma cells by decreasing the levels of antiapoptotic proteins and suppressing the activation of NF-κB. It was also reported that an exogenous H2S donor—DATS, an active component in garlic oil—at 100 μM inhibited the proliferation of A375 human melanoma cells by downregulating the Akt and ERK pathways. The gene discussed is AKT1; the disease is melanoma.