And overexpression of EGFR or treatment with AKT signaling activator significantly rescued the attenuated cell proliferation induced by TUC338 depletion, indicating that the ceRNA regulatory axis of TUC338/miR-28-5p/EGFR/PI3K/AKT does exist in DLBCL cells. This evidence concerns the gene PCBP2-OT1 and diffuse large B-cell lymphoma.