Disappointingly in vitro stimulations at the time with overlapping peptides throughout the IAPP protein failed to identify a stimulating epitope, but experiments in which NOD mice bred to carry the BALB/c genomic region were protected from T1D induction by the BDC-6.9 clone (33) leading to the conclusion that the functional epitope was probably a post-translational modified form of an IAPP peptide. The gene discussed is IAPP; the disease is type 1 diabetes mellitus.