Apoptosis in myeloma can also be induced through the TLR3/TRIF/caspase-8 pathway (73), TLR3/IFN-β pathway (74) and TLR3/IFN-α/Bcl-2 pathway and caspase-3, caspase-9, X-IAP, cFLIP, and A20 (75). Here, TLR3 is linked to plasma cell myeloma.