While the CD159a-positive hypermature NK cells in NBM did not surpass 29%, we identified 2 MDS cases (out of n = 25) with at least 36%, and other 2 AML cases (out of n = 8) of 36% and 49% molecularly characterized by NPM1, FLT3 or FLT3-ITD mutations, respectively (Supplementary Figure 4). Here, FLT3 is linked to acute myeloid leukemia.