For wheeze at month 18, we found significant associations of UMC only in the asthma risk strata of the single-nucleotide polymorphisms at the 17q21 locus related to ORMDL3 (rs8076131) and GSDMB (rs7216389 and rs2290400, all p-values for interaction < 0.001). The gene discussed is ORMDL3; the disease is asthma.